This is revised and enlarged fifth edition of the textbook medicine. This is a pioneer publication comprehensively written by the Indian authors to cater to the needs of the undergraduate medical students practitioners students who attempt postgraduate entrance examinations and postgraduates in general medicine in the developing countries. The Indian sub continent has a unique disease spectrum which is a peculiar blend of the morbidity seen in the affluent countries and the entities seen in the developing countries. The text of this book encompasses this amalgam along with the discussion on the tropical diseases which have been dovetailed into other sections such as infections physical agents nutrition etc. to enhance their understanding and to present a more holistic picture.